Abstract
The present study shows that when L cells persistently infected with hemagglutinating virus of Japan (HVJ) (L-HVJ cells) were incubated at 32°, the interferon-producing capacity of the cells was suppressed and was restored by the temperature shift-up to 38°. Synthesis of envelope protein antigen was not detected in the L-HVJ cells incubated at 38° which could produce interferon. Moreover, glutamine-starved L-HVJ cells did produce interferon even at 32°. The relationship between the suppressed state of interferon production and synthesis of viral envelope protein is discussed.
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