Abstract
1. Large amounts of interferon were obtained in the spleen of rats intravenously injected with Sindbis virus or heat-killed E. coli. Peak values occurred 2 hours after E. coli and 6 to 12 hours after Sindbis administration. 2. It was demonstrated that fragmented spleen tissue derived from rats injected with Sindbis virus or heat-killed E. coli, produce an interferon-like substance when incubated in vitro in tissue culture medium. 3. Splenectomy reduced 7 times the serum interferon response to E. coli but did not affect that to Sindbis virus. 4. Under proper experimental conditions combined injections of E. coli and Sindbis virus acted synergistically on the interferon response. 5. Germfree reared rats responded equally well to endotoxin treatment as did conventional animals. 6. The injection of E. coli resulted in a “hypareactive” state which lasted several days and during which the spleen interferon yield after Sindbis challenge was decreased. Conversely, Sindbis virus also rendered the animals resistant to the interferon inducing effect of E. coli.
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