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Abstract
Summary Mouse L-cell interferon (IF) (0.03–30 units/ml) produces a concentration-dependent inhibition of both spontaneous and melanocyte hormone stimulated (MSH) melanogenesis in cultures of murine B-16 melanoma cells. This inhibition is synergistic with that produced by the tumor promoter 12-0-tetradecanoylphorbol-13 acetate (TPA). Both TPA and IF also inhibit the expression of tyrosinase activity. These and previous results suggest that the antitumor effects of IF may be due to modulation of cellular differentiation.
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