Abstract
Interferon inhibits uptake of the radiolabeled queuine analog, rQT 3, into cultured human fibroblasts. Simultaneous exposure to 10 nM phorbol-12, 13-didecanoate (PDD) potentiates interferon-induced inhibition of rQT 3 into cultured fibroblasts. All three major classes of human interferon tested affected uptake similarly, with fibroblasts derived beta-interferon being more effective in dose response than gamma or alpha interferons. This suggests that endogenous production of interferon by cultured cells, such as that observed during a low grade viral infection, inhibits queuine uptake and may subsequently lead to a decreased level of queuine modified transfer RNA. Queuine-hypomodified transfer RNA has been implicated in growth control, differentiation and neoplastic transformation.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Biochemical and Biophysical Research Communications
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
