Abstract
Behçet's disease is an inflammatory disease of unknown etiology which involves recurring oral and genital aphthous ulcers and ocular lesions as well as articular, vascular, and nervous system involvement. Focal segmental glomerulosclerosis (FSGS) is usually seen in viral infections, immune deficiency syndrome, sickle cell anemia, and hyperfiltration and secondary to interferon therapy. Here, we present a case of FSGS identified with kidney biopsy in a patient who had been diagnosed with Behçet's disease and received interferon-alpha treatment for uveitis and presented with acute renal failure and nephrotic syndrome associated with interferon.
Highlights
Behcet’s disease is an inflammatory disease of unknown etiology which involves recurring oral and genital aphthous ulcers and ocular lesions as well as articular, vascular, and nervous system involvement [1]
We present a case of focal segmental glomerulosclerosis (FSGS) in a patient who had been diagnosed with Behcet’s disease and received interferon-alpha treatment for uveitis and presented with acute renal failure and nephrotic syndrome associated with interferon
While primary or idiopathic FSGS is of unknown cause, secondary FSGS occurs after known cause
Summary
Behcet’s disease is an inflammatory disease of unknown etiology which involves recurring oral and genital aphthous ulcers and ocular lesions as well as articular, vascular, and nervous system involvement [1]. Interferon is used in ocular involvement of Behcet’s disease. Renal injury from interferon is typically mild and includes proteinuria, mild azotemia, and abnormalities in urinary findings [2]. There are few case reports of development of FSGS due to interferon therapy in patients with Behcet’s disease [3]. We present a case of focal segmental glomerulosclerosis (FSGS) in a patient who had been diagnosed with Behcet’s disease and received interferon-alpha treatment for uveitis and presented with acute renal failure and nephrotic syndrome associated with interferon
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