Abstract
Interferons are glycoproteins of heterogeneous composition produced by the living cell as a part of the immune response to a viral infection. They were discovered exactly half a century ago. They possess antineoplastic, antiviral and immunomodulatory activities. The therapeutically used forms are denoted by Greek letters indicating their origin: leukocytes, fibroblasts, and lymphocytes for interferon-alpha, -beta and -gamma, respectively. Both natural and recombinant interferons have been used in human medicine. Connection with polyethylene glycol assures the prolonged effect of interferon preparations. Currently they are applied for the elimination of viruses in the therapy of chronic hepatitis B and C and for inhibiting the progression of neoplasms in oncology.
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