Abstract
Summary Induction of and sensitivity to interferon were investigated in relation to virus persistence in congenital rubella. Rubella virus was found to be sensitive to human interferon in acutely infected tissue culture cells; however, virus yields from chronically infected cells were not altered by interferon. Serum and urine obtained from infants with congenital rubella during periods of active virus excretion did not contain detectable amounts of interferon. Vaccination of congenital rubella infants with either Edmonston B or Schwarz strain of live measles virus resulted in a clinical, immunologic and interferon response similar to that of normal children. The interferon-inducing capacity of the Schwarz strain was greater than that of the Edmonston B strain.
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