Abstract
BackgroundPrevious studies proved that interferon gamma (IFN-γ) gene polymorphisms were associated with the risk of hepatitis B virus (HBV) infection. However, the association between IFN-γ polymorphisms and HBV-related liver cirrhosis (HBV-LC) risk is still unclear.MethodsIFN-γ +874 T/A and +2109G/A genotypes were determined in 126 HBV-LC patients, 129 chronic hepatitis B(CHB) patients, and 173 early HBV infection controls using a sequence-specific primer-polymerase chain reaction and a polymerase chain reaction-restriction fragment length polymorphism, respectively.ResultsSignificant associations were observed between +2109A/G polymorphisms and HBV-LC risk in the co-dominant model (GG vs. AA: OR = 0.321, 95% CI = 0.130-0.793, P = 0.014), the allelic model (OR = 0.565, 95% CI = 0.388-0.825, P = 0.003), the dominant model (OR = 0.551, 95% CI = 0.344-0.883, P = 0.013), and the recessive model (OR = 0.385, 95% CI = 0.159-0.930, P = 0.034). In addition, haplotype analysis indicated that the T+874G+2109 haplotype significantly decreased the HBV-LC risk (OR = 0.106, 95% CI = 0.022-0.502, P = 0.000), and A+874A+2109 haplotype significantly increased the LC risk (OR = 1.485, 95% CI = 1.065-2.070, P = 0.019). No significant associations were observed between IFN-γ +874 T/A polymorphisms and HBV-LC risk, as well as the two single-nucleotide polymorphisms (SNPs) and CHB risk (P > 0.05).ConclusionsOur observations suggested a significant association of IFN-γ polymorphisms with HBV-LC risk in the Chinese population.
Highlights
Hepatitis B virus (HBV) infection is prevalent in the Chinese population and is associated with a variety of clinical consequences
Significant associations were observed between +2109A/G polymorphisms and hepatitis B virus (HBV)-liver cirrhosis (LC) risk in the co-dominant model (GG vs. AA: odds ratios (ORs) = 0.321, 95% confidence intervals (CIs) = 0.130-0.793, P = 0.014), the allelic model (G allele vs. A allele: OR = 0.565, 95% CI = 0.388-0.825, P = 0.003), the dominant model
We investigated the influence of these two single-nucleotide polymorphisms (SNPs) on the susceptibility of HBV-related liver cirrhosis (HBV-LC) in a Chinese population and identified the associations between the IFN-γ +2109A/G polymorphisms and HBV-LC risk
Summary
Hepatitis B virus (HBV) infection is prevalent in the Chinese population and is associated with a variety of clinical consequences. In the context of Cytokines play a fundamental role in the immunopathogenesis of HBV related diseases. Our previous studies found that cytokines gene polymorphisms, such as interleukin 4 (IL4), IL16, IL27, and IL23, were associated with the risk of HBV infection and HBV-related HCC [4,5,6,7]. Interferon gamma (IFN-γ) is a T-helper 1(Th1) proinflammatory cytokine that plays a pivotal role in antiviral activities and has antitumor and antiproliferative effects [8]. Previous studies proved that interferon gamma (IFN-γ) gene polymorphisms were associated with the risk of hepatitis B virus (HBV) infection. The association between IFN-γ polymorphisms and HBV-related liver cirrhosis (HBV-LC) risk is still unclear
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