Interferon gamma and transforming growth factor 1 beta levels in chronic pancreatitis patients with and without cholelithiasis

Abstract

s / Pancreatology 13 (2013) S2–S98 S57 Introduction:Masses in the head of the pancreas due to neuroimmune inflammation and hypertension inWirsung duct are two known reasons of severe abdominalgia in chronic pancreatitis (CP). Other reasons of a pain is a controversial. Aims: Demonstrate that so called «calcinates» into the parenchyma of the pancreas is really a stones in the tributary ducts. They are create a peripheral ductal hypertension. Patients m Izbicki (n1⁄42) and Berne’s modification of Beger procedure (n1⁄485). From 2010 yr for the first time in the world we carried out 13 antegrade double balloon enteroscopy (DBE) investigations of pancreaticojejunoanastomoses (PJA) lumen after elective surgery of CP. Results: Estimation of the results of the laser lithotripsy and cavitation during resection of pancreatic tissue (n1⁄435), morphology of latter and DBE data of PJA lumen examination (n1⁄413) allowed us to receive six evidences of the role of tributaryliths in the creation of peripheral ductal hypertension (PDH). This new reason of abdominal pain in CP was explained earlier as «peripheral parenchymal pressure». We proposed and introduced longitudinal pancreatotomyand laser cylindricwirsungectomy (n1⁄48) forelimination of PDH with restoration free outflow of pancreatic juce from tributary ducts. Conclusion: Detected by MRI, CT or US stones in parenchyma of the pancreas body («calcinates» earlier) are the indication for elimination of the PDH and abdominal pain. For the primary surgery of CP most effective was cylindric wirsungectomy.Izbicki. After Pargtingtone-Rochelle or classical Frey procedures indicated V-shaped resection of pancreas by Izbicki. PII-13 Abstract id: 116. Interferon gamma and transforming growth factor 1 beta levels in chronic pancreatitis patients with and without cholelithiasis I.N. Grigorieva , T.I. Romanova , E.V. Logvinenko , M.P. Grishaev , A.Yu. Yamlichanova . 1 Institute of Internal Medicine, Russia 2 JSC “Vector-Best”, Russia Introduction: Transforming growth factor beta 1 (TGF-beta1) plays a key role in promoting fi-brosis by stimulation the expression and deposition of extracellularmatrix and inhibition its degradation. Proinflammatory effect of interferon-gamma (IFN-gamma) proved an enhancement of its blood sera level in chronic pancreatitis (CP) exacerbation. IFN-gamma treatment strongly increased severity of pancreatic le-sions. Aims: To determine the IFN-gamma and TGF-beta 1 levels in the blood serum of CP patients (CPP) with or without cholelithiasis (CL). Materials m 1 – 9,6%, 2 – 90,4%. Alcohol consumption was not significantly different in CPP with ADH1B*1*2 and 2*2 genotypes, respectively: wine 84,0 74,3 and 47,8 26,6 ml/day, beer 469,3 169,1 and 443,5 112,2 ml/day, vermouth 10,0 0,1 and 13,2 2,4 ml/day, liquor 5,0 0,1 and5,5 0,5ml/day, vodka15,3 4,7 and25,7 7,0ml/day (p>0,05 inall cases). Conclusion: Among the surveyed CPP did not found ADH1B*1 homozygote. We found no significant differences in the dose of alcohol consumed by CPP in different ADH1B genotypes, but it should be noted that CPP with 2*2 genotype use higher doses of liquor and vodka, compared to those with 1*2 genotype. PII-16 Abstract id: 329. Loss of Ppar-gamma promotes KrasG12D-driven pancreatic ductal adenocarcinoma formation by inhibiting p53 function Wilhelm Sch€ onherr, Bo Kong, Sina Fritzsche, Nora Behler, Manja Thorwirth, Susanne Raulefs, Ivonne Regel, J€ org Kleeff, Christoph W.