Abstract
Ischemic optic neuropathy developed 3 to 6 months after the start of conventional-dose interferon therapy for malignancies in a 53 year-old woman with adenocarcinoma and a 67-year-old man with penile cancer. One case concurrently manifested peripheral neuropathy with histologic evidence of local vasculitis. After follow-up (5 years and 16 months), visual acuity, visual fields, and visual-evoked potentials had improved considerably but were still abnormal.
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