Abstract
The interferon (IFN) assay of the sera from the 26 patients with premalignant lesions such as lichen planus and leukoplakia arising in oral mucosa was performed by the plaque-reduction assay with vesicular stomatitis virus in FL cells derived from human amniotic membrane. When the serum IFN activity was characterized by acid treatment, significant increase of acid-stable IFN in the patients was found as compared with those in the normal controls. The titers of γ-Like IFN defined by anti-HuIFN- α and anti-HuIFN- β in the sera of patients of 50–79 years age group ( n = 17, P<0.002) showed a highly significant increase as compared with the relevant normal controls ( n = 20). All of the 26 patients were treated with topical administration of HuIFN- β. When the correlation between prognosis of the disease and titers of serum IFN was investigated by measuring γ-like IFN and acid-stable IFN in the sera of patients, all of 13 patients with good prognosis after the HuIFN- β therapy showed significantly decreased levels of y-like IFN ( P<0.01), whereas the serum level of acid-stable IFN after HuIFN- β therapy showed a significant increase compared to that before the therapy ( P<0.05). These findings indicate that the endogenous IFN system may be associated with the pathophysiology in patients with the oral mucosal lesions.
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More From: International Journal of Oral & Maxillofacial Surgery
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