Interferometric diffusing wave spectroscopy imaging with an electronically variable time-of-flight filter (Conference Presentation)

Abstract

Interferometric DOS (iDOS) is a new class of approaches that promises to improve the quantitative accuracy and depth specificity of blood flow index (BFI). iDOS techniques have alternatively achieved either time-of-flight (TOF) discrimination or highly parallel detection, but not both at once. Here, we break this barrier with a single iDOS instrument. Specifically, we show that rapid tuning of a temporally coherent laser during the sensor integration time increases the effective linewidth seen by a highly parallel interferometer. With a deep TOF filter applied to a high throughput interferometer, we demonstrate brain-specific BFI imaging.