Abstract
A NUMBER of drugs have been shown to interfere with the determination of urinary 17-ketosteroids (17-KS), 17-ketogenic steroids (17-KGS) and 17-hydroxycorticosteroids (17-OHCS). Meprobamate,1 triacetyloleandomycin2 and spironolactone3 have been shown to produce false elevation of both 17-KS and 17-OHCS values. Phenaglycodol4 and penicillin5 cause increases in both urinary 17-KS and urinary 17-KGS levels. Chlordiazepoxide hydrochloride (Librium) and etryptamine acetate (Monase) increase urinary 17-OHCS and depress urinary 17-KS values, whereas chlorpromazine (Thorazine) decreases urinary 17-OHCS while increasing urinary 17-KS.6 Hydroxyzine (Atarax) increases urinary 17-OHCS, and ethinamate (Valmid) raises urinary 17-KS.6 Reserpine suppresses both urinary 17-OHCS and urinary 17-KS levels.6 This report demonstrates . . .
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