Abstract
To the Editor: Hemoglobin (Hb)1 A1c (1) can be measured by cation-exchange HPLC, which separates hemoglobin fractions, including some Hb variants, based on the overall charge on the molecule. In populations for whom there is a high prevalence of homozygous sickle disease, it is advisable to routinely use to routinely use a separation technique such as HPLC because this allows identification of the HbS homozygous state (2). Sickle cell disease is marked by a shortened red cell life span, so clinical laboratories should not issue HbA1c results for cases of sickle disease. HbA1c immunoassays can be readily adapted to run on standard chemistry analyzers, but they …
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