Abstract
The family Asteraceae is the most numerous group within the Angiosperms. Plants from this family are studied for their chemical co mposition and biological act ivity. In these studies, the allelopathic, antimicrobial, cytotoxic and anti-inflammatory effects are highlighted. The aim of this study was to evaluate the action of the aqueous (AF1) and the oily (OF2) fract ions obtained fro m the ethanol extract of Baccharis coridifolia D. C. on the antimicrobial act ivity of antib iotics used in clinical treat ment. The drugs chloramphenicol (30 µg), norflo xacin (10 µg), sulfametho xazole / trimethoprim (75/23 µg), vancomycin (30 µg ) and amo xicillin (10 µg) were saturated with the fractions AF1 and OF2, and used pure for further comparison. The strains Escherichia coli ATCC 25922 and Staphylococcus aureus ATCC 25923 were used. The results showed that both fractions interfered on the activity of the antibiotics tested. Synergistic, antagonistic or indifferent behavior was observed in the interactions, with various degrees of susceptibility to the antib iotics tested. These results show that the use of products derived fro m plants can, in some cases, interfere with the effectiveness of antibiotics during clin ical therapy.
Highlights
Synthetic products started to appear more frequently in pharmacological treat ment after the Industrial Revolution and the development of organic chemistry
The m Inhib itory Concentration (MIC) va lues obtained served as a base to evaluate the effect of these extracts on a group of antibiotics used in clin ical therapy
A MIC equal to 12.50 mg/ L was used as a standard in the interference tests of the metabolites contained in the fract ions AF1 and OF2, when associated to mo lecules of antibiotics used in clinical therapy
Summary
Synthetic products started to appear more frequently in pharmacological treat ment after the Industrial Revolution and the development of organic chemistry. Natural products have not lost their place in therapy, being considered by the population as safe med icines, as 25% of d rugs prescribed world wide are of natural orig in[1]. The Asteraceae family is the most numerous systematic group within the Angiosperms, as it co mprises about 1,100 genera and 25,000 species. These plants are extremely varied in appearance, main ly including small herbs or shrubs, and rarely trees[2]. About 98% of the genera are small p lants, which are found in all types of habitats, but mainly in the mountainous tropical regions of south America[3]
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