Abstract
SUMMARY Hamsters inoculated with the TC-83 vaccine strain of Venezuelan encephalitis (VEE) virus were protected against a normally lethal challenge by virulent VEE virus, strain 68U201, inoculated 30 h after vaccination. Protection was correlated with significantly decreased levels of challenge virus in target tissues (spleen and bone marrow). Inhibition of challenge virus replication was correlated more closely with the interferon concentrations in spleen and bone marrow than with the vaccine virus infectivities in these tissues at the time of challenge. The induction of early defence mechanisms involves the efficient interaction of virus with the spleen; although this interaction is more efficient for TC-83 vaccine, virulent VEE viruses are sensitive to the induced protective mechanism. Interferon appears to be a mediator of this mechanism.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
