Abstract
Herpes simplex virus type 2 (HSV-2) markedly interferes with the replication of herpes simplex virus type 1 (HSV-1) upon simultaneous infection of HEp-2 cells, even under conditions where HSV-1 infection precedes that of HSV-2 by 3 hr. Interference required infective HSV-2 virus. The HSV-1 progeny of mixed infections were found to be phenotypically mixed. In most cases, prior infection with homologous strains slightly inhibits the replication of a superinfecting HSV-1 strain. An exception to this finding is HSV-1 strain MP, whose replication is accelerated by prior infection with nondefective HSV-1 strains. The implications of these findings as related to studies of defective HSV, to studies of the genetic interactions between HSV-1 and HSV-2, and to clinical infections with HSV are discussed.
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