Abstract
Graphene is well known for a variety of sensing applications due to its unique charge transport properties and ultra-thinness. Here we report, interfacing of electrochemically reduced graphene oxide (ERGO) with the polymer of erichrome black-T (PEBT) as a sensing platform for the simultaneous voltammetric determination of epinephrine (EP), uric acid (UA) and folic acid (FA). The reduction of graphene oxide (GO) and the polymerization of EBT was enabled using cyclic voltammetry (CV). Electrochemical impedance spectroscopy (EIS) and CV have been probed to study the electron transfer kinetics of the modified electrodes. An enhanced sensitivity towards the EP, UA and FA electrochemical oxidation has been observed after the modification of GCE with PEBT/ERGO. The sensor is able to detect simultaneously EP, UA and FA in their mixture at well-defined peak potential resolution. The proposed method allowed for the determination of EP, UA and FA in the presence of other interfering species with the limit of detection of 0.4 μM, 1 μM and 4.0 μM respectively. The fabricated PEBT/ERGO/GCE successfully used for the simultaneous determination of the analytes in blood sera samples with acceptable recovery rates.
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