Abstract
The adsorption process at the mercury | aqueous solution interface (NaClO 4 + NaOH, pH 12) of a series of benzenesulfonamides and benzoic acids is interpreted using some calculated structural indexes (superdelocalisability, electron density, shape of HOMO). The relations among these indexes and the adsorption free energy (at constant potential) indicate that the combined effects on the local electronic properties of the molecule, induced by the different substituents, greatly affect the interfacial behaviour, mainly when substitution on the amidic nitrogen of benzenesulfonamides is involved. This fact is confirmation that in the biological action of the pharmacologically active compounds, a possible adsorption step can be regarded as the one limiting the biological activity.
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