Abstract
To develop a new biodegradable scaffold biomaterial, synthesized CO3Ap was mixed with neutralized collagen gel and lyophilized into sponges. X-ray diffraction and FT-IR analyses, together with chemical analysis, indicated that synthesized CO3Ap had crystallinity and a chemical composition similar to bone. SEM observation showed that the CO3Ap-collagen sponge had a suitable pore size for cell invasion. When these sponge-frame complexes with rh-BMP2 were implanted beneath the periosteum cranii of rats, sufficient new bone was created at the surface of the periosteum cranii after 4 weeks’ implantation. Furthermore, when a CO3Ap-collagen sponge containing the SVVYGLR peptide was implanted into a tissue defect created in a rat tibia, the migration of numerous vascular endothelial cells, as well as prominent angiogenesis inside the graft, could be detected after 1 week. These CO3Ap-collagen sponges with highly functional modifications are expected to be used as hard-tissue scaffold biomaterials for the therapeutic purpose of rapid healing.
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