Abstract
Perla, and Perla and Sandberg1, 2 in their work on the reproductive behavior of rats have demonstrated a metabolic interdependence of manganese and vitamin B1. The present study was planned to provide information on the metabolism of manganese, copper and iron during the development of and recovery from vitamin B1 deficiency. Since the changes in copper and iron metabolism were not sufficiently constant to suggest a definite role of these metals in relation to vitamin B1, the metabolism of manganese only will be discussed.Twenty-two male and female albino rats of about 3 months of age were used in the experiment. They were kept in metabolism cages as described previously.3 Since only negligible amounts of Mn, Cu and Fe are excreted in the urine, feces only were collected twice a week. Feces and food were analyzed for Mn,4 Cu,5 and Fe.6 Blood pyruvic acid7 was determined weekly in control groups of rats that were kept only for this purpose.The rats received the Sherman-Spohn vitamin B1-deficient diet as mo...
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