Abstract
Hair loss represents a condition that adversely affects the social life of patients. The most common cause is androgenetic alopecia (AGA), which is a genetically determined progressive hair-loss condition involving 5α-reductase. In this study, a novel anti-baldness agent based on Interconnected PolymerS TeChnology (IPSTiC), which is an effective strategy for the delivery of bioactive molecules, was developed. This product (IPSTiC patch hair) is based on a polymeric blend consisting of high molecular weight hyaluronic acid and soybean proteins and is able to improve efficacy and stability of bioactive ingredients such as Origanum vulgare leaf extract, Camellia Sinensis leaf extract, and Capsicum Annuum fruit extract. The efficacy of the developed anti-baldness agent was investigated by performing several tests including NO radical and 5α-reductase inhibition assays, stability studies under different conditions, and in vitro diffusion studies using Franz cells. The biocompatibility of IPSTiC patch hair was also evaluated by in vitro analysis of the pro-sensitising potential and EPISKIN model. The obtained results confirmed both the efficacy and safety of IPSTiC patch hair supporting the potential use of this product in the topical treatment of AGA.
Highlights
Hair loss represents a harmful condition that adversely affects the quality of social life of patients
The most common one is represented by androgenetic alopecia (AGA), which is a genetically determined hair-loss hereditary condition affecting a large number of both men and women [1,2]
In the present research study, Origanum vulgare leaf extract, Camellia Sinensis leaf extract, and Capsicum Annuum fruit extract were employed as sources of bioactive compounds to prepare an innovative anti-baldness agent, IPSTiC patch hair, based on a polymeric blend consisting of high molecular weight hyaluronic acid and soybean proteins
Summary
Hair loss represents a harmful condition that adversely affects the quality of social life of patients. Camellia Sinensis exerts a significant hair growth promoting activity mainly due to its phytoconstituent epigallocatechin 3-gallate, which acts via proliferative and anti-apoptotic effects on dermal papilla cells and is able to inhibit 5α-reductase [39,40,41,42,43]. Intradermal injection of capsaicin caused anagen induction in mice [49] Given these characteristics, the aim of the present research study was the development of an innovative anti-baldness agent, which combines the hair growth promoting activities of bioactive ingredients, such as Origanum vulgare leaf extract, Camellia Sinensis leaf extract, and Capsicum Annuum fruit extract, with the higher stability and long-lasting effect due to the presence of a polymeric blend consisting of high molecular weight hyaluronic acid and soybean proteins
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