Abstract
The backscatter coefficient (BSC) as a function of frequency is a system and operator independent parameter. It is the basis for some quantitative ultrasound (QUS) based on spectral analysis being translated into clinical use. This study aims to extend previous work in well‐characterized physical phantoms to live animals where tissue properties are unknown. Six Sprague Dawley rats with spontaneous mammary tumors (five fibroadenomas and one carcinoma) were imaged with three clinical systems (Zonare Z.one, Ultrasonix RP, and Siemens S2000) and one single element laboratory system. Data were acquired from approximately the same region of the tumor with each scanner using independent setups. Scans of a reference phantom and Plexiglas plate were acquired for the clinical and laboratory systems, respectively. The data were analyzed using methods developed by the respective research group. BSC versus frequency plots show agreement in magnitude and trend among the different systems. The BSC estimates overlap each other, showing no more variability between systems than between consecutive imaging planes demonstrating agreement across multiple platforms and varied processing techniques between laboratories. Results support the potential to base diagnoses on QUS parameters. [Work was supported by NIH Grant R01CA111289.]
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