Abstract
Semi-packed columns containing an array of micropillars embedded within an open rectangular column structure are a new class of micro gas chromatography (μGC) columns introduced to provide higher separation efficiency and higher sample capacity. Three different semi-packed column configurations are evaluated with respect to pillar spacing along the flow direction and number of pillars across channel. The efficiencies of semi-packed columns, in terms of height-equivalent-to-a-theoretical-plate (HETP), are compared with two microfabricated open-rectangular columns. According to simulation results, arranging the pillars in a symmetrical configuration with spacing equal to the post dimension can suppress multi-path flows. Experimental results confirm the simulation prediction as the design with 2 μm post spacing (SP1) demonstrates the highest performance among other designs. SP1 is found to have HETP of 0.010 cm (15 000 plates/m) at an optimal velocity of 18 cm/s. An open channel design with comparable channel width yields an HETP of 0.025 cm (6000 plates/m) at an optimal velocity of 45 cm/s. The pressure drop in semi-packed columns is experimentally measured to be ~ 9 kPa which falls within the practical range of microfabricated pumps.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
