Abstract
In recent years, it has become evident that lymphocyte are particularly adapted to form short-lived intercellular connections with the cells they scan. Such connections allow the transfer of membrane-anchored proteins, plasma membrane (PM) fragments, and even microRNAs.1-5 This “unorthodox” intercellular information transfer occurs through various incompletely defined mechanisms. For example, during the formation of an immunological synapse, lymphocytes snatch PM fragments (also termed trogocytosis) and cell surface proteins from antigen-presenting cells (APCs).6 Additionally, lymphocytes can form intercellular networks through actin-supported, long-range PM extensions, termed tunneling nanotubes (TNTs), which have been shown to facilitate the intercellular transfer of calcium-mediated signals, vesicles, and even viruses.7
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