Abstract
The anterior-posterior and dorsal-ventral axes of the Diosophila egg and embryo are established during oogen esis as the egg is being formed. The mechanisms under lying this process involve intercellular signaling events, including bidirectional communication between germline and somatic cells, and local cell-cell interactions in the soma. On the molecular level, these interactions ap pear to be mediated by a small number of intercellular signaling systems, including the Epidermal growth fac tor receptor [Egfr] and Notch systems, that are used mul tiple times during oogenesis to trigger different develop mental switches. The precisely regulated interplay be tween these various signaling systems forms a network of interdependencies that leads to the establishment of both the anterior-posterior and dorsal-ventral polarity in the egg chamber and embryo. Because both the Egfr and Notch signaling systems are widely conserved, the mechanisms involved in the regulation of these pro cesses in Drosophila oogenesis may serve as a paradigm for understanding intercellular signaling events in other organisms.
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