Intercellular Adhesion Molecule 1 Is Important for the Development of Severe Experimental Malaria but Is Not Required for Leukocyte Adhesion in the Brain

Abstract

Plasmodium berghei-infected mice, a well-recognized model of experimental cerebral malaria (ECM), exhibit a systemic inflammatory response. Most investigators hypothesize that leukocytes bind to endothelial cells via intercellular adhesion molecule 1...