Abstract
ABSTRACT Similarity analysis of complicated chromatographic profiles is a potential protocol for the authentication and quality control of traditional Chinese medicine to guarantee prospective biological activity. In this work, a high-performance liquid chromatography (HPLC) method was established to identify and control the inter-assay quality of extract from Artemisia frigida Willd. Meanwhile, a partial least squares regression (PLSR) was applied to construct a spectrum–effect relationship between the HPLC fingerprints and the total antioxidant capacity of the extract from Artemisia frigida Willd. The similarity correlation coefficient of 10 batches of extract was ≥0.948 could guarantee the 10 batches of showed the inter-assay stability of antioxidant capacity of extract from Artemisia frigida Willd. Moreover, PLSR analysis showed that four efficacy-related components were closely related to antioxidant effect. Therefore, this study provided a flexible and efficient method for the quality and the stable biological activity assessment of Artemisia frigida Willd.
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