Abstract
A hospital-based case-control study was conducted to investigate the potential interaction between dietary factors and polymorphisms in phase II metabolic enzymes GSTM1 and GSTT1, associated with head and neck cancer risk. The study included 103 histologically confirmed incident cases and 101 controls. Food intake was estimated with a validated food frequency questionnaire. The gene polymorphisms were evaluated by PCR. Increased risk was observed in the highest tertile of beef consumption in the presence of the GSTM1 (OR = 10.79; 95%CI: 2.17-53.64) and GSTT1 null alleles (OR = 3.41; 95%CI: 0.43-27.21). Assessment of dietary intake considering the ratio between animal product and vegetable consumption showed OR = 2.35 (95%CI: 0.27-19.85) in the intermediate tertile and OR = 3.36 (95%CI: 0.41-27.03) in the highest tertile. The results suggest a possible interaction between meat intake and GSTM1/GSTT1 polymorphisms in modulating the risk of head and neck cancer, influenced by vegetable consumption.
Highlights
A hospital-based case-control study was conducted to investigate the potential interaction between dietary factors and polymorphisms in phase II metabolic enzymes GSTM1 and GSTT1, associated with head and neck cancer risk
The gene polymorphisms were evaluated by PCR
Increased risk was observed in the highest tertile of beef consumption in the presence of the GSTM1 (OR = 10.79; 95%CI: 2.17-53.64) and GSTT1 null alleles (OR = 3.41; 95%CI: 0.43-27.21)
Summary
Trata-se de um estudo do tipo caso-controle, de base hospitalar, aprovado pelo Comitê de Ética do Complexo Hospitalar Heliópolis e pela Comissão Nacional de Ética em Pesquisa (CONEP; parecer 04/99). Entre dezembro de 2000 e dezembro de 2003, 103 pacientes com carcinoma de células escamosas de cabeça e pescoço, histologicamente confirmados, foram recrutados no pré-operatório (92 homens, 11 mulheres, idade média 53±9 anos) do Serviço de Cirurgia de Cabeça e Pescoço do Complexo Hospitalar Heliópolis. Foram incluídos neste estudo os casos incidentes de câncer classificados com os códigos C00 a C14 (cavidade oral e orofaringe) de acordo com a 10a revisão da Classificação Internacional de Doenças (CID-10) 12, com exceção dos casos classificados como C00.0, C00.1, C00.2, relativos ao lábio externo e C11 (nasofaringe). Os controles (93 homens, 8 mulheres, idade média 53±10 anos), não poderiam ter história ou suspeita de câncer de cavidade oral ou de laringe no presente ou passado. Pacientes admitidos no hospital por doenças associadas negativamente ou positivamente com os fatores de risco conhecidos ou suspeitos para câncer de cavidade oral ou laringe não foram incluídos no estudo.
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