Interactive mapping of language and memory with the GE2REC protocol

Sonja Banjac,Emilie Cousin,Philippe Kahane,Célise Haldin,Laurent Lamalle,Cédric Pichat,Monica Baciu,Elise Roger,Marcela Perrone-Bertolotti,Lorella Minotti

doi:10.1007/s11682-020-00355-x

Abstract

Previous studies have highlighted the importance of considering cognitive functions from a dynamic and interactive perspective and multiple evidence was brought for a language and memory interaction. In this study performed with healthy participants, we present a new protocol entitled GE2REC that interactively accesses the neural representation of language-and-memory network. This protocol consists of three runs related to each other, providing a link between tasks, in order to assure an interactive measure of linguistic and episodic memory processes. GE2REC consists of a sentence generation (GE) in the auditory modality and two recollecting (2REC) memory tasks, one recognition performed in the visual modality, and another one recall performed in the auditory modality. Its efficiency was evaluated in 20 healthy volunteers using a 3T MR imager. Our results corroborate the ability of GE2REC to robustly activate fronto-temporo-parietal language network as well as temporal mesial, prefrontal and parietal cortices in encoding during sentence generation and recognition. GE2REC is useful because it: (a) requires simultaneous and interactive language-and-memory processes and jointly maps their neural basis; (b) explores encoding and retrieval, managing to elicit activation of mesial temporal structures; (c) is easy to perform, hence being suitable for more restrictive settings, and (d) has an ecological dimension of tasks and stimuli. GE2REC may be useful for studying neuroplasticity of cognitive functions, especially in patients with temporal lobe epilepsy who show reorganization of both language and memory networks. Overall, GE2REC can provide valuable information in terms of the practical foundation of exploration language and memory interconnection.

Highlights

It is suggested that the base of proper cognitive functioning is the dynamic interaction between different neuropsychologicalElectronic supplementary material The online version of this article contains supplementary material, which is available to authorized users.Univ
The activations obtained for a single participant and the standard deviations across all subjects are provided in the supplementary material (Fig. S1, Table S1) as an illustration of the potential use of this protocol on an individual level
We propose the GE2REC protocol developed for interactive mapping of the language-and-memory network and present its validation in healthy participants

Summary

Introduction

It is suggested that the base of proper cognitive functioning is the dynamic interaction between different neuropsychological. Grenoble Alpes, GIN, Synchronisation et modulation des Réseaux Neuronaux dans l’Epilepsie’ and Neurology Department, F-38000 Grenoble, France domains (Kellermann et al 2016). There is growing evidence suggesting that memory and language influence each other more than previously thought (Huettig and Janse 2016; Moscovitch et al 2016; Vogelzang et al 2017). It was suggested that there are brain systems commonalities between these functions (Ullman 2004) and that lexical-semantic aspects of language are highly dependent on the declarative memory system, which is accomplished through the hippocampus (Duff and Brown-Schmidt 2012)

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