Abstract
Osteosarcomas have many established risk factors, both genetic and environmental, but by themselves these explain only part of the total cancer incidence. Bisphenol A (BPA) is an environmental estrogen associated with risk of several kinds of tumour. The lysyl oxidase gene (LOX) may also contribute to risk of tumours including osteosarcomas. Here, we investigated possible interactions of BPA and a LOX polymorphism on the risk of osteosarcoma. The present hospital-based case-control study included 106 cancer patients and 112 controls from a Chinese population. Internal burden of BPA exposure was assessed using high-performance liquid chromatography-mass spectrometry (HPLC-MS) method. Genotypes were determined using PCR-RFLP methods. Compared with those in low BPA exposure group, subjects with BPA more than or equal to median value had significant increased risk of osteosarcoma among subjects who carried GC or CC genotypes. A significant interaction with BPA level and the -22 G/C polymorphism was observed for osteosarcoma overall, osteosarcoma affecting knee and osteosarcoma affecting hip, as P(forinteraction) = 0.036 for osteosarcoma overall; P(forinteraction) = 0.024 for osteosarcoma affecting knee; and P(forinteraction) = 0.017 for osteosarcoma affecting hip. The results suggest that BPA exposure interacts with the -22 G/C polymorphism of the LOX gene to increase the risk of osteosarcoma.
Highlights
Osteosarcoma is one of the most commonly diagnosed malignant diseases and the leading cause of pediatric cancer-related mortality worldwide(Hameed and Dorfman, 2011)
The results suggest that Bisphenol A (BPA) exposure interacts with the -22G/C polymorphism of the lysyl oxidase gene (LOX) gene to increase the risk of osteosarcoma
It has been reported that bisphenol A (BPA), an environmental estrogens which can mimic the action of normal estrogen (Melzer et al, 2011), is a definite risk factor associated with several tumors (Fernandez et al, 2006; Ericson et al, 2007; Duan et al, 2012)
Summary
Osteosarcoma is one of the most commonly diagnosed malignant diseases and the leading cause of pediatric cancer-related mortality worldwide(Hameed and Dorfman, 2011). We investigated possible interactions of BPA and a LOX polymorphism on the risk of osteosarcoma. Method: The present hospital-based case-control study included 106 cancer patients and 112 controls from a Chinese population.
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