Abstract
BackgroundDNA methylation of Cadherin 13 (CDH13), a tumor suppressor gene is associated with gene repression and carcinogenesis. We determined the relation of dietary fat and sex with CDH13 cg02263260 methylation in Taiwanese adults.MethodsData of 870 eligible participants (430 men and 440 women) between 30 and 70 years were obtained from the Taiwan Biobank (TWB) database. The association of dietary fat and sex with CDH13 cg02263260 methylation was determined using multiple linear regression.ResultsThe association between sex and cg02263260 methylation was significant: beta-coefficient (β) = 0.00532; 95% confidence interval (CI) = 0.00195–0.00868. Moreover, the interaction between sex and dietary fat on cg02263260 methylation was significant (P-value = 0.0145). After stratification by sex, the association of dietary fat with cg02263260 methylation was significant only in women. Specifically, high dietary fat was positively associated with cg02263260 methylation in women (β = 0.00597; 95% CI = 0.00061–0.01133) and the test for trend was significant (P-value = 0.0283).ConclusionHigh fat intake was significantly associated with higher cg02263260 methylation in women and the test for trend was significant. These findings suggest that the association of fat intake and CDH13 cg02263260 might vary by sex and CDH13 cg02263260 methylation levels in women might increase as fat intake increases.
Highlights
deoxy‐ ribonucleic acid (DNA) methylation of Cadherin 13 (CDH13), a tumor suppressor gene is associated with gene repres‐ sion and carcinogenesis
The CDH13 cg02263260 methylation levels, dietary fat, body mass index, body fat, cigarette smoking, alcohol/tea intake, vegetarian diet, high-density lipoprotein cholesterol, and triglycerides in men and women were significantly different at P < 0.05 (Table 1)
A significant association existed between sex and cg02263260 methylation; with the female sex as the reference group, the male sex was significantly associated with higher CDH13 cg02263260 methylation levels
Summary
DNA methylation of Cadherin 13 (CDH13), a tumor suppressor gene is associated with gene repres‐ sion and carcinogenesis. Unhealthy dietary habits exacerbate the risk of chronic diseases by inducing inflammation and enhancing the production of reactive oxygen species (ROS), which are DNA methylation is a well-recognized epigenetic phenomenon characterized by the addition or removal of a methyl group (CH3) predominantly at the fifth position of cytosine in a CpG dinucleotide, forming 5-methylcytosine [13,14,15,16] It mediates external effects on gene expressions and plays crucial roles in cellular development, differentiation, and pathogenesis [13,14,15,16,17,18]. Re-expression of the gene has been associated with suppressed oncogenic processes like proliferation, invasiveness, and angiogenesis [26, 27]
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