Abstract
BackgroundLittle is known about the interactions of apolipoprotein (Apo) A5 gene polymorphisms and alcohol consumption on serum lipid profiles. The present study was undertaken to detect the interactions of ApoA5–1131T>C, c.553G>T and c.457G>A polymorphisms and alcohol consumption on serum lipid levels.Methodology/Principal FindingsA total of 516 nondrinkers and 514 drinkers were randomly selected from our previous stratified randomized cluster samples. Genotyping was performed by polymerase chain reaction and restriction fragment length polymorphism. The levels of serum total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), ApoA1 and ApoB were higher in drinkers than in nondrinkers (P<0.05–0.001). The genotypic and allelic frequencies of three loci were not different between the two groups. The interactions between –1131T>C genotypes and alcohol consumption on ApoB levels (P<0.05) and the ApoA1/ApoB ratio (P<0.01), between c.553G>T genotypes and alcohol consumption on low-density lipoprotein cholesterol (LDL-C) levels (P<0.05) and the ApoA1/ApoB ratio (P<0.05), and between c.457G>A genotypes and alcohol consumption on TG levels (P<0.001) were detected by factorial regression analysis after controlling for potential confounders. Four haplotypes (T-G-G, C-G-G, T-A-G and C-G-T) had frequencies ranging from 0.06 to 0.87. Three haplotypes (C-G-G, T-A-G, and C-G-T) were significantly associated with serum lipid parameters. The –1131T>C genotypes were correlated with TG, and c.553G>T and c.457G>A genotypes were associated with HDL-C levels in nondrinkers (P<0.05 for all). For drinkers, the –1131T>C genotypes were correlated with TC, TG, LDL-C, ApoB levels and the ApoA1/ApoB ratio (P<0.01 for all); c.553G>T genotypes were correlated with TC, TG, HDL-C and LDL-C levels (P<0.05–0.01); and c.457G>A genotypes were associated with TG, LDL-C, ApoA1 and ApoB levels (P<0.05–0.01).ConclusionsThe differences in some serum lipid parameters between the drinkers and nondrinkers might partly result from different interactions of the ApoA5 gene polymorphisms and alcohol consumption.
Highlights
Dyslipidemia has become a major health problem in many countries because of its high prevalence and a causal relationship with serious medical condition such as coronary artery disease (CAD), hypertension and stroke [1]
The differences in some serum lipid parameters between the drinkers and nondrinkers might partly result from different interactions of the ApoA5 gene polymorphisms and alcohol consumption
Serum lipid levels between nondrinkers and drinkers The levels of total cholesterol (TC), TG, high-density lipoprotein cholesterol (HDL-C), ApoA1 and ApoB were higher in drinkers than in nondrinkers (P,0.05–0.001)
Summary
Dyslipidemia has become a major health problem in many countries because of its high prevalence and a causal relationship with serious medical condition such as coronary artery disease (CAD), hypertension and stroke [1]. Numerous studies have evaluated the influence of alcohol consumption on CAD and plasma lipid concentrations. A moderate intake of alcohol is associated with protection against CAD, probably due in part to a dose-dependent increase in high-density lipoprotein cholesterol (HDL-C) [9,10,11]. A decrease in low-density lipoprotein cholesterol (LDL-C) with increased alcohol intake has been reported in some studies, but this effect is less consistent and probably depends on the combination of one or more unmeasured factors [12]. Little is known about the interactions of apolipoprotein (Apo) A5 gene polymorphisms and alcohol consumption on serum lipid profiles. The present study was undertaken to detect the interactions of ApoA5–1131T.C, c.553G.T and c.457G.A polymorphisms and alcohol consumption on serum lipid levels
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