Abstract
Objective: To detect the interactions between six functional polymorphisms in ABCA1 and obesity in Kazakhs with low HDL-C levels. Methods: A total of 204 patients with low HDL-C and 207 health control subjects, which were randomly selected from among 5692 adult Kazakhs, were matched for age and sex. We genotyped ABCA1 single nucleotide polymorphisms of rs2515602, rs3890182, rs2275542, rs2230806, rs1800976, and rs4149313. Results: (1) The genotypic and allelic frequencies of rs2515602, rs2230806 and rs4149313 were different between normal HDL-C and low HDL-C subjects, the genotypic frequency of rs2275542 was also different between normal HDL-C and low HDL-C subjects (p < 0.05); (2) the level of HDL-C (rs2515602 and rs2275542) in normal HDL-C subjects were different among the genotypes (p < 0.05); the levels of TC, LDL-C (rs2515602, rs4149313); TG (rs2515602, rs1800976, rs4149313) in low HDL-C patients were different among the genotypes (p < 0.05); (3) interactions between the rs3890182, rs2275542, rs180096, and rs4149313 polymorphisms in ABCA1 gene and obesity may be associated with low HDL-C disease; (4) the C-C-C-A-A-G, T-C-C-A-A-A, T-C-C-A-A-G, C-C-C-A-A-A, C-T-G-G-A-A, and T-T-C-G-A-A haplotypes were significant between the subjects with normal HDL-C and low HDL-C level (p < 0.05). Conclusions: The differences in serum lipid levels between normal HDL-C and low HDL-C subjects among Kazakhs might partly result from ABCA1 gene polymorphisms; ABCA1 gene polymorphisms may be associated with low HDL-C disease; the low HDL-C disease might partly result from interactions between ABCA1 gene polymorphisms and obesity; the C-C-C-A-A-G, T-C-C-A-A-A, and T-C-C-A-A-G haplotypes may serve as risk factors of low HDL-C disease among Kazakhs, the C-C-C-A-A-A, C-T-G-G-A-A, and T-T-C-G-A-A haplotypes may serve as protective factor of low HDL-C disease among Kazakhs.
Highlights
Dyslipidemia has become one of the most serious public health problems in the world because of its high prevalence [1,2] and a causal relationship of conditions such as coronary artery disease (CAD) [3], obesity and metabolic syndrome [4]
Body mass index (BMI), hip circumference, waist circumference, TG, fasting plasma glucose (FPG), and obesity prevalence were higher in the cases compared with controls (p < 0.05), whereas serum total cholesterol (TC), low density lipoprotein cholesterin (LDL-C), and high-density lipoprotein-cholesterol (HDL-C) levels were lower in the case group than in the control group (p < 0.05)
The present study shows that there was no significant difference in the genotype and allelic frequencies of ATP-binding cassette transporter A1 (ABCA1) rs1800976 and rs3890182 polymorphisms between the normal HDL-C group and low HDL-C group
Summary
Dyslipidemia has become one of the most serious public health problems in the world because of its high prevalence [1,2] and a causal relationship of conditions such as coronary artery disease (CAD) [3], obesity and metabolic syndrome [4]. As one of the important phenotype of dyslipidemia and it shows higher prevalence than other three kinds of components in dyslipidemia [5,6]. Low HDL-C damage to health is mainly concentrated. Res. Public Health 2016, 13, 176; doi:10.3390/ijerph13020176 www.mdpi.com/journal/ijerph
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: International Journal of Environmental Research and Public Health
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
