Abstract
Considering that tissue injury caused by laparotomy significantly increases the liver synthesis of plasma fibrinogen, and that PGE 1, bradykinini and histamine are released into the injured tissues, the effect of above mentioned inflammatory agents and of adrenal medulla on plasma fibrinogen levels in rats was studied. The subcutaneous administration of PGE 1, bradykinin or histamine does not modify plasma fibrinogen levels acting independently comparing with non-injected animals or injected with the drug vehicle. Bradykinin + histamine did not modify plasma fibrinogen levels either. However the administration of prostaglandin E 1 + bradykinin + histamine reproduced the increase of fibrinogen characteristics of laparotomy. This increase was partially but significantly inhibited in rats that had undergone bilateral removal of the adrenal medulla or administration of PGE 1 + bradykinin + histamine + bupivacaine (a local anesthetic), but it was not modified when the adrenal medullectomy was unilateral. It is concluded that plasma fibrinogen increase is obtained only when PGE 1 acts in presence of bradykinin or histamine and the adrenal medulla should be partially responsible for said increase.
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