Abstract
The interactions between a nonsteroidal anti-inflammatory drugs, oxyphenbutazone (OPB), with two cyclodextrins, β-cyclodextrin (β-CD) and γ-cyclodextrin (γ-CD), have been studied in an aqueous medium and in the solid state. Differential scanning calorimetry, hot stage microscopy, thermogravimetric analysis and X-ray diffraction (XRD) powder have been the techniques used to characterize the interactions in the solid state. Although OPB forms inclusion compounds with β- and γ-CD in the aqueous medium, only the OPB/γ-CD inclusion compound was obtained in the solid state by the kneading method. The XRD powder used at different temperatures has proven be a useful tool in characterizing the behaviour of these binary systems.
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