Abstract
PIP: All drugs either directly or indirectly interact with the concentrations of nutrients and their derivatives in an organism. Pharmacology is ultimately inseparable from nutrition: From ancient times man has made use of natural products for medicinal purposes. Since nutritional requirements are species-specific, drugs based on nutritional requirements of man but unhelpful to disease-producing microorganisms could be developed. Also, drugs could be developed to beneficially effect specific, highly differentiated tissues of man. Mechanisms of drug-nutrient interaction involve similarities in chemical structure, enzyme inhibition, interference with systems necessary for transport and storage of nutrients, interference with genetic apparatus, and alteration of functional characteristics of cell membranes. Oral contraceptives may have many effects on nutrients, including vitamin-B6 deficiency, effects on other vitamin concentrations, and derangement of folate function.
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