Abstract
Summary The uptake of exogenous norepinephrine by subcellular fractions of rat brain has been investigated in a sucrose NaCl Tris buffer medium. Although the uptake of norepinephrine has been shown to be a temperature-dependent process, these studies were run at 0–4°C so that the results would be compatible with subsequent binding experiments. The uptake of this catecholamine which occurs at 0–4°C is inhibited by pyrogallol, bufotenin, and ergotamine, and is activated by serotonin and psilocybin. Plots of norepinephrine uptake as a function of the equilibrium norepinephrine concentration have indicated that the uptake of norepinephrine is a multicomponent phenomenon, and this is supported by inhibition data. One component appears to be associated with the microsomal fraction and is inhibited by serotonin, pyrogallol, and ergotamine, and activated by psilocybin. A second component appears to be associated with nerve-ending particles and exhibits a very similar drug profile. A third component also appears to be associated with nerve-ending particles and is inhibited by ergotamine but activated by bufotenin, serotonin, and psilocybin.
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