Abstract
The interactions of nabumetone (NAB) with α-cyclodextrin (α-CD) andγ-cyclodextrin (γ-CD) were studied in aqueous solution by meansof phase-solubility analysis. Solid dispersions of NAB with α-cyclodextrin(α-CD), β-cyclodextrin (β-CD), methylβ- (Mβ-CD),hydroxypropylβ-cyclodextrin (HPβ-CD) were prepared by coevaporationand kneading and also by coprecipitation in the case of γ-CD. X-ray diffractometry, thermal analysis and infrared spectroscopy (FTIR) were used to study the possibility of complexation of the drug with the different cyclodextrins. Solid dispersions of nabumetone with γ-CD showed a remarkable improvement in the dissolution rate of nabumetone.
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