Abstract
In this study, the chelation of Hypocrellin A (HA) with Al3+ in water solution has been synthesized, and the interactions of HA and Al3+–HA complex with calf thymus DNA are in detail compared by UV–vis and fluorescence spectroscopic techniques, circular dichroism spectroscopy and viscosity measurement. The experiment results suggest that HA and Al3+–HA complex both could bind to CT DNA by intercalation mode, and double helix of DNA was damaged. Moreover, Al3+–HA complex not only displays higher absorption at therapeutic window but also displays stronger binding affinity to CT DNA than HA.
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Schedule a callMore From: Spectrochimica Acta Part A: Molecular Spectroscopy
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