Abstract
Acridines are moderate binders of nucleic acids due to hydrophobic interactions leading to auto-insertion between two adjacent base pairs of nucleic acids (intercalation). Use of multiple acridines in one molecule can cause polyintercalation and enhanced binding to the nucleic acids. Intercalation is widely employed for targeting of cargos to proximity of nucleic acids. Moreover, when the nucleic acid processing enzymes are inhibited by intercalated acridines, the cure of various cancer or viral diseases can be achieved. Usually, acridines preferred site rich on GC moieties at dsDNA and G4 at quadruplexes . Structural aspects of interaction with nucleic acids can help to the reader in design of specific binders, especially for targeting of quadruplexes involved in cancer.
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