Abstract
The thermodynamic parameters enthalpy and entropy of the interaction between calcium(II) or copper(II) with 5'-UMP, 5'-CMP, 5'-AMP, 5'-GMP or 5'-IMP in aqueous solution were determined calorimetrically (ionic strength adjusted to 0.1 with tetramethylammonium bromide) at 25 degrees C and pH 7 for Ca(II) or pH 3-5 for Cu(II). The experimental conditions were carefully selected to avoid polynuclear complex formation and nucleotide self-stacking. The calorimetric data confirm the tendency toward macrochelation which was indicated by Sigel after very precise potentiometric studies, and which follows the order Cu(II) > Ca(II) for the metal ions and GMP > IMP > AMP > CMP = UMP for the nucleotides. Macrochelate formation for these metal-nucleoside monophosphate complexes is energetically favorable and entropically unfavorable.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
