Abstract
The formation of extracellular inflammatory mediators during blood contact with foreign surfaces was measured by allowing whole human blood to clot during 10 min in hydrophilic or hydrophobic glass tubes and transferring the serum fraction to a pure granulocyte preparation, containing a fluorescent calcium probe, Calcium Green. The serum fraction formed in contact with hydrophilic glass tubes gave a higher intracellular calcium transient in the probe cells. The formation of the granulocyte activator was attenuated by pre-adsorption of cellulose ethers to the glass surface. The results show that blood coagulation in contact with different materials affects the production of inflammatory mediators in the serum fraction. We also demonstrate the possibility to influence the extracellular signal transduction at foreign materials in contact with blood by modifying the surface chemistry of the material.
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