Interactions between the MMP-3 gene rs591058 polymorphism and occupational risk factors contribute to the increased risk for lumbar disk herniation: A case-control study.

Abstract

ObjectiveLumbar disk herniation (LDH) is a complex condition based on lumbar disk degeneration (LDD). Previous studies have shown that genetic factors are highly associated with the severity and risk for LDH. This case‐control study was aimed to evaluate the association between the matrix metalloproteinase (MMP)‐3 gene rs591058 C/T polymorphism and LDH risk in a southern Chinese population.MethodsA total of 231 LDH patients and 312 healthy controls were recruited in this study. Genotyping was analyzed using a standard polymerase chain reaction and restriction fragment length polymorphism (PCR‐RFLP).ResultsIt was observed that TT genotype or T allele carriers of the MMP‐3 gene rs591058 C/T polymorphism was more likely associated with an increased risk for LDH. Subgroup analyses showed the following characteristics increased the risk for LDH: female sex; cigarette smoking; and alcohol consumption. Furthermore, individuals with high whole body vibration, bending/twisting, and lifting were associated with an increased risk for LDH.ConclusionTaken together, these data indicated that the MMP‐3 gene rs591058 C/T polymorphism was associated with an increased risk for LDH. The MMP‐3 gene rs591058 C/T polymorphism might serve as a clinical indicator and marker for LDH risk in the Chinese population.