Abstract
BackgroundIn order to develop colloidal drug carriers with desired properties, it is important to determine physico-chemical characteristics of these systems. Bile salt mixed micelles are extensively studied as novel drug delivery systems. The objective of the present investigation is to develop and characterize mixed micelles of nonionic (Triton X-100) or anionic (sodium lauryl ether sulfate) surfactant having oxyethylene groups in the polar head and following bile salts: cholate, deoxycholate and 7-oxodeoxycholate.ResultsThe micellization behaviour of binary anionic-nonionic and anionic-anionic surfactant mixtures was investigated by conductivity and surface tension measurements. The results of the study have been analyzed using Clint's, Rubingh's, and Motomura's theories for mixed binary systems. The negative values of the interaction parameter indicate synergism between micelle building units. It was noticed that Triton X-100 and sodium lauryl ether sulfate generate the weakest synergistic interactions with sodium deoxycholate, while 7-oxodeoxycholate creates the strongest attractive interaction with investigated co-surfactants.ConclusionIt was concluded that increased synergistic interactions can be attributed to the larger number of hydrophilic groups at α side of the bile salts. Additionally, 7-oxo group of 7-oxodeoxycholate enhance attractive interactions with selected co-surfactants more than 7-hydroxyl group of sodium cholate.
Highlights
In order to develop colloidal drug carriers with desired properties, it is important to determine physico-chemical characteristics of these systems
It is known that bile salts form micelles at concentrations above the critical micelle concentration [3,6,7]
The cmc values of individual bile salts (D, C, and OD) and Sodium lauryl ether sulfate (SLES) were acquired through conductivity and surface tension studies
Summary
In order to develop colloidal drug carriers with desired properties, it is important to determine physico-chemical characteristics of these systems. Bile salt mixed micelles are extensively studied as novel drug delivery systems. The objective of the present investigation is to develop and characterize mixed micelles of nonionic (Triton X-100) or anionic (sodium lauryl ether sulfate) surfactant having oxyethylene groups in the polar head and following bile salts: cholate, deoxycholate and 7-oxodeoxycholate. Bile salts are steroid compounds with planar amphiphilic properties [1]. These surfactant characteristics result from the combination of the polar hydroxyl groups on the concave a-face and the methyl groups on the convex b-face [1,2]. The more hydrophobic bile salt is, the lower critical micelle concentration it has, due to more stable hydrophobic aggregations [6,7]
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