Abstract
Abstract Interactions between oxotremorine and physostigmine or dyflos have been investigated in mice using doses giving approximately 50% inhibition of mouse brain cholinesterase. Oxotremorine LD50 was unaffected by pretreatment of mice with the anticholinesterases. Its ED50 (tremor) was decreased by physostigmine and neostigmine but not by dyflos. Dyflos antagonized oxotremorine hypothermia, physostigmine was without effect. Oxotremorine did not alter the inhibitory activity of the anticholinesterases. The lack of potentiation of oxotremorine by cholinesterase inhibitors suggests it acts directly in these tests by a mechanism independent of its ability to increase tissue acetylcholine concentration.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
