Abstract
Mental Stress and Coronary Vasomotion. Coronary artery disease often presents late in its course with adverse events like myocardial infarction and sudden death. One of the earlier manifestations of the disease is transient myocardial ischemia. It is clear that physical and mental stress can precipitate ischemic episodes during daily life. Through studies done in the cardiac catheterization laboratory, we found evidence suggesting that mental stress causes an increase in oxygen demand and a decrease in blood supply by causing vasoconstriction of the atherosclerotic epicardial coronary arteries. Local factors like endothelial dilator function may play a significant role in the vasomotor response to mental stress.
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