Abstract

Several preliminary versions of the article describing the model put forward by Jacques Monod, Jeffries Wyman and Jean-Pierre Changeux to account for the properties of regulatory enzymes have been preserved in the Archives of the Institut Pasteur in Paris. As a result, it has been possible to reconstitute a rather precise chronology of the main scientific events that led to the elaboration of this model. I am describing here the scientific interactions that took place between Jeffries Wyman and Jacques Monod from January 1963 to January 1965 on key issues concerning the structure and function of oligomeric proteins.

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