Abstract
Interactions between [4- 14C]cortisol or [4- 14C]corticosterone and fractions of the liver and muscle cell of the rat have been studied in vivo and in vitro, in normal and adrenalectomized animals. Multiple equilibrium dialysis and a novel procedure, “equilibrium fractionation”, have been used. Greater amounts of cortisol or corticosterone are bound by the mitochondrial fraction of the rat-liver cell than by the nuclei, microsomes and supernatant. Studies in vitro have shown that the affinity of normal rat-liver mitochondria is greater for corticosterone than for cortisol; essentially the same results were obtained with adrenalectomized rats. No significant binding of the two steroids was observed to the subcellular fractions obtained from skeletal muscle of the rat.
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