Abstract
Nifedipine inhibits the uptake of [ 3H]adenosine into rat cerebral cortical synaptosomes with an IC 50 value of 1.1 μM. When applied by iontophoresis onto rat cerebral cortical neurons it potentiated the depressant effects of adenosine on spontaneous firing. Some of the calcium-antagonist actions of nifedipine may be mediated by adenosine.
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